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KMID : 0370219850290040216
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Yakhak Hoeji
1985 Volume.29 No. 4 p.216 ~ p.219
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Pharmacokinetics of Acetaminophen in Rabbits with Experimental Renal Failure
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최준식/Choi JS
이종기/Lee CK
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Abstract
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The pharmacokinetics of acetaminophen were investigated in rabbits with folate-induced renal failure. The blood level, the area under the blood concentration curve(AUC) and the biological half-life were increased significantly, and the urinary excretion was decreased significantly as compared with those of normal rabbits. Serum creatinine concentration and AUC, creatinine clearance and renal clearance have linear relationship respectively. Dosage regimen of acetaminophen was considered to be adjusted in renal failure.
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